Colorado Lotto - Pick the Winning Lottery Numbers
Use this guide to determine when to play a specific game in the Colorado lotto.  This page focuses on the odds of playing any particular game and what I call the "Expected Value" to determine when is the best time to play.
Colorado
Powerball - Avoid
Based on the odds of playing the Powerball, the Jackpot should be at least $161,134,919 before you consider playing.  I do not recommend playing Powerball games because the odds are far too astronomical for you to affect. Note that you can also add to your potential winnings by choosing the powerplay option but this does not increase your odds of winning.
Lotto - Play
The Colorado Lotto is a good game to play because the potential earnings is actually worth taking the risk to play.  You only have to choose from 42 numbers which greatly increases your odds of winning.  You should play this game when the Jackpot reaches$4,363,597.
Cash 5 - Avoid
This game is a money maker for the government, granted all games are technically money makers.  Since the jackpot is a static $20,000 you will never reach a reasonable jackpot that would make this game worth playing.  The Dollar Value per Odd for this game is $.45... Terrible.
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Colorado Lottery Scratch Off Info
It is odd to see that the Colorado Lotto doesn't have more options for big lottery games.  They do, however, have a lot of different scratch offs to play.  I don't recommend playing scratch offs because the odds of you winning the big prize or any subsequent prize after that are determined by how many of those tickets have been purchase and how many prizes have been won.  It could be that as tickets are bought, your odds of winning get better because tere are less losing tickets out there.  Or they could be getting worse.  You just can't tell.  Here are some quick tips for playing the Colorado scratch off games.

18 Million Dollar Money Machine - The top prize is only $50,000.  That's a hard sell for a $20 ticket.
A Couple $10 Tickets worth looking at - The Crossword Tripler and Holiday Snowbank both have $250,000 prizes.